Mechanisms and Models in Heart Failure
نویسندگان
چکیده
منابع مشابه
Mechanisms and models in heart failure: A combinatorial approach.
Despite repeated attempts to develop a unifying hypothesis that explains the clinical syndrome of heart failure, no single conceptual paradigm for heart failure has withstood the test of time. One logical explanation for our inability to define the syndrome of heart failure in precise mechanistic and/or clinical terms is that the clinical syndrome of heart failure almost certainly represents th...
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Although neurohumoral antagonism has successfully reduced heart failure morbidity and mortality, the residual disability and death rate remains unacceptably high. Though abnormalities of myocardial metabolism are associated with heart failure, recent data suggest that heart failure may itself promote metabolic changes such as insulin resistance, in part through neurohumoral activation. A detrim...
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The syndrome of heart failure may arise from different causes but there are features that are common to all: myocardial fibrosis, desensitization of b-adrenergic receptor signalling, excitation-contraction uncoupling, myosin isoform switch, altered energy utilization and ‘‘cell loss’’. These unifying features imply that the molecular pathways that underpin them are activated in most, if not all...
متن کاملHeart failure and mouse models.
Heart failure is a common, complex condition with a poor prognosis and increasing incidence. The syndrome of heart failure comprises changes in electrophysiology, contraction and energy metabolism. This complexity, and the interaction of the clinical syndrome with very frequently concurrent medical conditions such as diabetes, means that animal modelling of heart failure is difficult. The curre...
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Despite the remarkable therapeutic advances in the treatment of chronic heart failure, it remains a condition marked by progressive deterioration and premature mortality. Our treatments slow the rate of descent, and some reset the survival curve upward, but decline is inevitable. There is, however, great heterogeneity in the journeys traveled by individual heart failure patients. Heart failure ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2021
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.121.318158